研究领域

主要研究方向为多肽药物化学。围绕多肽分子的结构改造、功能研究、及成药性等问题，发展绿色温和、快速高效、高选择性和兼容性的正交修饰策略及其应用研究。

一、发表论文及获批专利

1. Guangjun Bao⁺, Xinyi Song⁺, Yiping Li, Zeyuan He, Quan Zuo, Ruiyao E, Tingli Yu, Kai Li, Junqiu Xie^*, Wangsheng Sun^* & Rui Wang^*. Orthogonal bioconjugation targeting cysteine-containing peptides and proteins using alkyl thianthrenium salts. Nat. Commun. 2024, 15, 6909.

2. Guangjun Bao⁺, Peng Wang⁺, Guofeng Li⁺, Changjun Yu, Yiping Li, Yuyang Liu, Zeyuan He, Tiantian Zhao, Jing Rao, Junqiu Xie, Liang Hong, Wangsheng Sun^*, and Rui Wang^*. 1,3-Dipolar Cycloaddition between Dehydroalanines and C,N-Cyclic Azomethine Imines: Application to Late-Stage Peptide Modification. Angew. Chem. Int. Ed., 2021, 60, 5331−5338.

3. Guangjun Bao, Peng Wang, Jingyue Li, Xinyi Song, Tingli Yu, Jiao Zhang, Yiping Li, Zeyuan He, Ruiyao E, Xiaokang Miao, Junqiu Xie, Jingman Ni^*, Rui Wang^* & Wangsheng Sun^*. Dimethyl Sulfoxide/Visible-Light Comediated Chemoselective C–S Bond Formation Between Tryptophans and Thiophenols Enables Site-Selective Functionalization of Peptides. CCS Chem. 2024, 6, 1547−1556.

4. Guangjun Bao, Peng Wang, Xiaomin Guo, Yiping Li, Zeyuan He, Xinyi Song, Ruiyao E, Tingli Yu, Junqiu Xie^*, and Wangsheng Sun^*. Visible-Light Mediated Deoxygenation of Carboxylic Acid for Late-Stage Peptide Modification Targeting Dehydroalanine. Org. Lett. 2023, 25, 8338−8343.

5. Gongming Zhu⁺, Guangjun Bao⁺, Yiping Li, Wangsheng Sun^*, Jing Li, Liang Hong^* and Rui Wang^*. Efficient Catalytic Kinetic Resolution of Spiro-epoxyoxindoles with Concomitant Asymmetric Friedel–Crafts Alkylation of Indoles. Angew. Chem. Int. Ed., 2017, 56, 5332−5335.

6. Guofeng Li⁺, Guangjun Bao⁺, Gongming Zhu, Yiping Li, Liwu Huang, Wangsheng Sun^*, Liang Hong^* and Rui Wang^*. Regio- and stereospecific Friedel-Crafts alkylation of indoles with spiro-epoxyoxindoles. Org. Biomol. Chem., 2018, 16, 3655.

7. Gongming Zhu, Guangjun Bao, Yiping Li, Junxian Yang, Wangsheng Sun^*, Jing Li, Liang Hong^* and Rui Wang^*. Chiral Phosphoric Acid Catalyzed Asymmetric Oxidative Dearomatization of Naphthols with Quinones. Org. Lett., 2016, 18, 5288−5291.

8. Zeyuan He, Yuyang Liu, Guangjun Bao, Yiping Li, Xiufang Zhao, Quan Zuo, Kai Li, Wangsheng Sun^* and Rui Wang. Intermolecular sulfur atom transfer cascade enabled late-stage introduction of sulfilimines into peptides. Chem. Sci., 2024, 15, 17058.

9. Yiping Li, Jingyue Li, Guangjun Bao, Changjun Yu, Yuyang Liu, Zeyuan He, Peng Wang, Wen Ma, Junqiu Xie, Wangsheng Sun^*, and Rui Wang^*. NDTP Mediated Direct Rapid Amide and Peptide Synthesis without Epimerization. Org. Lett. 2022, 24, 1169−1174.

10. Gongming Zhu⁺, Yiping Li⁺, Guangjun Bao, Wangsheng Sun,^* Liwu Huang, Liang Hong^* and Rui Wang^*. Catalytic Kinetic Resolution of Spiro-Epoxyoxindoles with 1‑Naphthols: Switchable Asymmetric Tandem Dearomatization/Oxa-Michael Reaction and Friedel-Crafts Alkylation of 1‑Naphtholsat the C4 Position. ACS Catal., 2018, 8, 1810−1816.

11. Bangzhi Zhang, Yiping Li, Guangjun Bao, Gongming Zhu, Jing Li, Juanli Wang, Bao Zhang, Wangsheng Sun^*, Liang Hong^* and Rui Wang. Regio- and stereoselective ring-opening reaction of spiro-epoxyoxindoles with ammonia under catalyst-free conditions. Green Chem., 2017, 19, 2107−2110.

12. Gongming Zhu, Junxian Yang, Guangjun Bao, Ming Zhang, Jing Li, Yiping Li, Wangsheng Sun^*, Liang Hong^* and Rui Wang^*. Catalyst-controlled switch of regioselectivity in the asymmetric allylic alkylation of oxazolones with MBHCs. Chem. Commun., 2016, 52, 7882−7885.

13. Quan Zuo, Yiping Li, Xuanliang Lai, Guangjun Bao, Lu Chen, Zeyuan He, Xinyi Song, Ruiyao E, Pengxin Wang, Yuntao Shi, Huixin Luo, Wangsheng Sun^*, and Rui Wang^*. Cysteine-Specific Multifaceted Bioconjugation of Peptides and Proteins Using 5-Substituted 1,2,3-Triazines. Adv. Sci. 2024, 2308491.

14. Yuyang Liu,^‡ Guofeng Li,^‡ Wen Ma, Guangjun Bao, Yiping Li, Zeyuan He, Zhaoqing Xu^*, Rui Wang^* and Wangsheng Sun^*. Late-stage peptide modification and macrocyclization enabled by tertiary amine catalyzed tryptophan allylation. Chem. Sci., 2024, 15, 11099.

15. Ming Zhang, Wangsheng Sun, Gongming Zhu, Guangjun Bao, Bangzhi Zhang, Liang Hong^*, Min Li^*, and Rui Wang^*. Enantioselective Dearomative Arylation of Isoquinolines. ACS Catal., 2016, 6, 5290−5294.  

16. Yuyang Liu, Zeyuan He, Wen Ma, Guangjun Bao, Yiping Li, Changjun Yu, Jingyue Li, Ruiyao E, Zhaoqing Xu^*, Rui Wang^*, and Wangsheng Sun^*. Copper(I)-Catalyzed Late-Stage Introduction of Oxime Ethers into Peptides at the Carboxylic Acid Site. Org. Lett. 2022, 24, 9248−9253.

17. Junxian Yang, Wangsheng Sun^*, Zeyuan He, Changjun Yu, Guangjun Bao, Yiping Li, Yuyang Liu, Liang Hong^*, and Rui Wang^*. Access to α,γ-Diamino Diacid Derivatives via Organocatalytic Asymmetric 1,4-Addition of Azlactones and Dehydroalanines, Org. Lett. 2018, 20, 7080−7084.

18. Changjun Yu, Ruiyao E, Yingying An, Xiaomin Guo, Guangjun Bao, Yiping Li, Junqiu Xie, Wangsheng Sun^*. Michael Addition Reaction between Dehydroalanines and Phosphites Enabled the Introduction of Phosphonates into Oligopeptides. Org. Lett. 2024, 26, 4767−4772.

19. Changjun Yu, Ruiyao E., Xiao-Wei Zhang, Wen-Qian Hu, Guangjun Bao, Yiping Li, Yuyang Liu, Zeyuan He, Jingyue Li, Wen Ma, Ling-Yun Mou^*, Rui Wang^*, and Wangsheng Sun^*. NaClO-Mediated Cross Installation of Indoles and Azoles Benefits Anticancer Hit Discovery. ChemMedChem 2023, 18, e202200651.

20. Bochuan Deng, Jiao Zhang, Xiang Zhang, Dan Wang, Lu Cheng, Ping Su, Tingli Yu, Guangjun Bao, Guofeng Li, Liang Hong, Xiaokang Miao, Wenle Yang, Rui Wang^*, and Junqiu Xie^*. Novel Peptide DR3penA as a Low-Toxicity Antirenal Fibrosis Agent by Suppressing the TGF-β1/miR-212-5p/Low-Density Lipoprotein Receptor Class a Domain Containing 4/Smad Axis. ACS Pharmacol. Transl. Sci. 2024, 7, 1126−1141.

21. Yingying An, Xiaomin Guo, Tiantian Yan, Yue Jia, Ruoyan Jiao, Xinyu Cai, Bochuan Deng, Guangjun Bao, Yiping Li, Wenle Yang, Rui Wang^*, Wangsheng Sun^*, Junqiu Xie^*. Enhancing the stability and therapeutic potential of the antimicrobial peptide Feleucin-K3 against Multidrug-Resistant a. Baumannii through rational utilization of a D-amino acid substitution strategy. Biochemical Pharmacology 2024, 225, 116269.

22. Sanhu Gou, Li Wang, Chao Zhong, Xinyue Chen, Xu Ouyang, Beibei Li, Guangjun Bao, Hui Liu, Yun Zhang, Jingman Ni^*. A novel apoA-I mimetic peptide suppresses atherosclerosis by promoting physiological HDL function in apoE^−/− mice. Br J Pharmacol., 2020, 177, 4627−4644.

23. Guofeng Li, Ying Yao, Zheng Wang, Man Zhao, Jiecheng Xu, Liwu Huang, Gongming Zhu, Guangjun Bao, Wangsheng Sun, Liang Hong^*, and Rui Wang, Switchable Skeletal Rearrangement of Dihydroisobenzofuran Acetals with Indoles. Org. Lett. 2019, 21, 4313−4317.

24. 获批国家发明专利：王锐；孙旺盛；包广军；王鹏，可见光催化精准修饰色氨酸吲哚C-2位构建C-S结构的方法及其应用，专利号：ZL 2022 1 0705486.3。

二、科研项目

1. 国家自然科学基金青年科学基金项目（22307052），“光诱导硫酚/硫醇与色氨酸的偶联在多肽和蛋白质修饰中的应用研究”，（30万），2024.01−2026.12，主持。

2. 中国博士后科学基金第70批面上资助（2021M701533），“犬尿氨酸多样性修饰的新型达托霉素类似物抗临床耐药菌活性研究”，（8万），2021.11−2023.04，主持。

3. 甘肃省自然科学基金青年科技基金（23JRRA1103），“双环达托霉素类似物构建及其抗临床耐药菌活性研究中的应用”，（4万），2023.07−2025.06，主持。