1. 肿瘤免疫学

2. 肿瘤细胞分子生物学

3. 肿瘤药物基因组学

4. 肿瘤分子生物学诊断标志物

科研情况简介：

主持甘肃省自然科学基金两项、甘肃省青年科学基金项目一项、北京市亦城合作发展基金会项目一项、兰州市城关区科技计划项目一项及中央高校基本科研业务费专项资金自由探索项目两项，参与多项国家自然科学基金项目和甘肃省自然科学基金项目

主要发表论文：

(1) Tian Y#, Xie B#, Wang S#, Ma X#, Deng H, Ma L, Li L. PRKD3 Promotes Proliferation of Liver Cancer Cell: A Downstream Proteomics Profiling Study. American Journal of Translational Research, accepted.

(2) Ma X, Wang Z, Wang S, Tian Y, Xie B, Li J, Ma B, Li L. The assessment of circulating tumor DNA associated with Wnt/β-catenin signaling pathway as a diagnostic tool for liver cancer: a systematic review and meta-analysis. Expert Rev Anticancer Ther. 2024 Mar-Apr; 24(3-4):155-167.

(3) Xie B#,*, Zhao L#, Zhang Z#, Zhou C, Tian Y, Kang Y, Chen J, Wei H*, Li L*. CADM1 impairs the effect of miR-1246 on promoting cell cycle progression in chemo-resistant leukemia cells. BMC Cancer. 2023 Oct 9;23(1):955.

(4) Qin M, Chen G, Hou J, Wang L, Wang Q, Wang L, Jiang D, Hu Y, Xie B, Chen J, Wei H, Xu G. Tumor-infiltrating lymphocyte: features and prognosis of lymphocytes infiltration on colorectal cancer. Bioengineered. 2022 Jun;13(6):14872-14888.

(5) Yan J#, Xie B#, Zou S, Huang L, Tian Y, Li J, Peng Z, Liu Z, Ma B*, Li L*. Value of biomarkers in epithelial-mesenchymal transition models of liver cancer under different interventions: a meta-analysis. Future Oncol. 2022 Nov;18(36):4031-4045.

(6) Yi J, Gong X, Yin XY, Wang L, Hou JX, Chen J, Xie B, Chen G, Wang LN, Wang XY, Wang DC, Wei HL. Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells. Front Oncol. 2022 Oct 24;12:988528.

(7) Wang L, Yi J, Yin XY, Hou JX, Chen J, Xie B, Chen G, Wang QF, Wang LN, Wang XY, Sun J, Huo LM, Che TJ, Wei HL. Vacuolating Cytotoxin A Triggers Mitophagy in Helicobacter pylori-Infected Human Gastric Epithelium Cells. Front Oncol. 2022 Jul 14;12:881829.

(8) Chen J, Sun J, Wang Q, Du Y, Cheng J, Yi J, Xie B, Jin S, Chen G, Wang L, Wang X, Wei H. Systemic Deficiency of PTEN Accelerates Breast Cancer Growth and Metastasis. Front Oncol. 2022 Mar 18;12:825484.

(9) Yan J#, Xie B#, Tian Y, Huang L, Zou S, Peng Z, Liu Z, Li L. iTRAQ-Based Proteome Profiling of Differentially Expressed Proteins in Insulin-Resistant Human Hepatocellular Carcinoma. Front Cell Dev Biol. 2022 Feb 25;10:836041.

(10) Chen J, Zhou C, Yi J, Sun J, Xie B, Zhang Z, Wang Q, Chen G, Jin S, Hou J, Qin M, Wang L, Wei H. Metformin and arsenic trioxide synergize to trigger Parkin/pink1-dependent mitophagic cell death in human cervical cancer HeLa cells. J Cancer. 2021 Aug 28;12(21):6310-6319.

(11) Yi J, Wang L, Wang XY, Sun J, Yin XY, Hou JX, Chen J, Xie B, Wei HL. Suppression Of Aberrant Activation Of NF-κB Pathway In Drug-resistant Leukemia Stem Cells Contributes To Parthenolide-potentiated Reversal Of Drug Resistance In Leukemia. J Cancer. 2021 Jul 25;12(18):5519-5529.

(12) Xie B#, Li L#, Zhang Z, Zhao L, Cheng J, Zhou C, Cheng J, Yan J, Chen J, Yi J, Wang B, Jin S, Wei H. MicroRNA-1246 by Targeting AXIN2 and GSK-3β Overcomes Drug Resistance and Induces Apoptosis in Chemo-resistant Leukemia Cells. J Cancer. 2021 May 13;12(14):4196-4208.

(13) Lin L, Wei H, Yi J, Xie B, Chen J, Zhou C, Wang L, Yang Y. Chronic CagA-positive Helicobacter pylori infection with MNNG stimulation synergistically induces mesenchymal and cancer stem cell-like properties in gastric mucosal epithelial cells. J Cell Biochem. 2019 Oct;120(10):17635-17649.

(14) Chen J, Wei H, Cheng J, Xie B, Wang B, Yi J, Tian B, Liu Z, Wang F, Zhang Z. Characteristics of doxorubicin-selected multidrug-resistant human leukemia HL-60 cells with tolerance to arsenic trioxide and contribution of leukemia stem cells. Oncol Lett. 2018 Jan;15(1):1255-1262.

(15) Xie B#, Nagalingam A#, Kuppusamy P, Muniraj N, Langford P, Győrffy B, Saxena NK*, Sharma D*. Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes. Sci Rep. 2017 Jan 10;7:40070.

(16) Chen J, Cheng J, Yi J, Xie B, Lin L, Liu Z, Zhao H, Wang B, Ai Z, Yang Y, Wei H. Differential expression and response to arsenic stress of MRPs and ASAN1 determine sensitivity of classical multidrug-resistant leukemia cells to arsenic trioxide. Leuk Res. 2016 Nov;50:116-122.

(17) Li L, Li G, Wei H, Sun J, Chen J, Xie B, Wang B, Gu J, Li C, Tian B, Wang F. The endoplasmic reticulum stress response is associated with insulin resistance-mediated drug resistance in HepG2 cells. Neoplasma. 2015;62(2):180-90.

(18) Li CL, Wei HL, Chen J, Wang B, Xie B, Fan LL, Li LJ. Arsenic trioxide induces autophagy and antitumor effects in Burkitt's lymphoma Raji cells. Oncol Rep. 2014 Oct;32(4):1557-63.

(19) Li CL, Wei HL, Chen J, Wang B, Xie B, Fan LL, Li LJ. Ebb-and-flow of macroautophagy and chaperone-mediated autophagy in Raji cells induced by starvation and arsenic trioxide. Asian Pac J Cancer Prev. 2014;15(14):5715-9.

(20) Li LJ, Li GD, Wei HL, Chen J, Liu YM, Li F, Xie B, Wang B, Li CL. Insulin resistance reduces sensitivity to Cis-platinum and promotes adhesion, migration and invasion in HepG2 cells. Asian Pac J Cancer Prev. 2014;15(7):3123-8.

(21) Cheng J, Chen J, Xie B, Wei HL. Acquired multidrug resistance in human K562/ADM cells is associated with enhanced autophagy. Toxicol Mech Methods. 2013 Nov;23(9):678-83.

(22) Chen J, Wei H, Xie B, Wang B, Cheng J, Cheng J. Endoplasmic reticulum stress contributes to arsenic trioxide-induced apoptosis in drug-sensitive and -resistant leukemia cells. Leuk Res. 2012 Dec;36(12):1526-35.

(23) Cheng J, Wei HL, Chen J, Xie B. Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy. Toxicol Mech Methods. 2012 Sep;22(7):512-9.

(24) Xie B, Nakanishi S, Guo Q, Xia F, Yan G, An J, Li L, Serikawa T, Kuramoto T, Zhang Z. A novel middle-wavelength opsin (M-opsin) null-mutation in the retinal cone dysfunction rat. Exp Eye Res. 2010 Jul;91(1):26-33.

(25) 谢蓓，赵磊，孙静，张丽娟，库本高志，魏虎来. 二乙基亚硝胺诱导建立Apc基因突变大鼠与F344大鼠肝癌模型的比较.实验动物与比较医学.2017; 37(3): 191-197.

(26) 蔺莉; 谢蓓; 康雅琼; 张杰; 一种诱导细胞恶性转化培养模型的方法, 2019-03-27, 中国, ZL 2019 1 0237016.7 (专利)

(27) 魏虎来; 陈静; 程杰; 谢蓓; 易娟; 王蓓; 人白血病HL-60细胞耐药细胞株HL-60/RS细胞及其制备方法, 2014-05-21, 中国, ZL 2014 1 0217030.8 (专利)

(28) 实验动物视觉功能客观评定新技术体系的建立与应用, 陕西省人民政府, 科技进步, 省部二等奖, 2021 (科研奖励)